Overview
Date: On-demand
Watch NowIn this webinar, Peter W. Laird, professor at the Van Andel Research Institute, will discuss the development of a mouse DNA methylation array that contains 296,070 probes representing the diversity of mouse DNA methylation biology. Laird will present a comprehensive validation of this array platform and discuss the applications for comparative epigenomics, genomic imprinting, epigenetic inhibitors, PDX assessment, backcross tracing, and epigenetic clocks. This Infinium Mouse Methylation BeadChip (version MM285) is widely accessible to the research community and will accelerate high sample-throughput studies in this important model organism.
Laird and colleagues have dissected DNA methylation processes associated with differentiation, aging, and tumorigenesis. Notably, the team found that tissue-specific methylation signatures localize to binding sites for transcription factors controlling the corresponding tissue development. Age-associated hypermethylation is enriched at regions of Polycomb repression, while hypomethylation is enhanced at regions bound by cohesin complex members. ApcMin/+ polyp-associated hypermethylation affects enhancers regulating intestinal differentiation, while hypomethylation targets AP-1 binding sites.
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Peter W. Laird, PhD Peter W. Laird is a professor at the Van Andel Institute (VAI) in Grand Rapids, Michigan. He earned his bachelor’s and master’s degree, cum laude, from the University of Leiden, Netherlands. He trained for his doctorate with Piet Borst at the Netherlands Cancer Institute and performed postdoctoral work with Anton Berns of the Netherlands Cancer Institute and Rudolf Jaenisch at the Whitehead Institute for Biomedical Research in Cambridge, Massachusetts. In 1996 he joined the faculty at the University of Southern California, where he served as the founding director of the USC Epigenome Center and as leader of the Epigenetics and Regulation Program of the Norris Comprehensive Cancer Center. He relocated to VAI in 2014. Laird published the first demonstration of a causal role for DNA methylation in oncogenesis (Cell, 1995). He developed two formerly widely used DNA methylation analysis techniques, COmbined Bisulfite Restriction Analysis (COBRA) and MethyLight. He contributed new insights into the origins of DNA methylation abnormalities in cancer. Laird oversaw all DNA methylation data production for The Cancer Genome Atlas (TCGA) and was an active contributor to numerous TCGA analysis working groups, including as co-chair of the Gastric, Esophageal, Gastrointestinal, and Cell-Of-Origin Analysis Working Groups. |
