Modeling human macrophage activation with transcriptome profiling

Modeling human macrophage activation with transcriptome profiling

Joachim L. Schultze, Director, Genomics and Immune Regulation, Life and Medical Sciences Institute (LIMES), University of Bonn
Topic: Human Genetics & Genetic Disease

Increasing evidence from murine studies show that macrophages compute input signals from their tissue environment to generate specific functional programs both during homeostasis and inflammation. To translate these concepts to human macrophage biology, reductionist models have been made to study global reprogramming of human macrophages on the transcriptional level. Based on recent spectrum model of human macrophage activation (Xue et al., Immunity, 2014), the following topics will be addressed during the 1-hour presentation:

  • How specific is signal integration in macrophages?
  • What are major transcriptional hubs of macrophage activation?
  • Can such models be utilized to define in vivo macrophage biology?


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