Epigenetics is the study of heritable changes in gene activity caused by mechanisms other than DNA sequence changes. Epigenetic analysis research can involve studying alterations in DNA methylation, DNA-protein interactions, chromatin accessibility, histone modifications, and more.
Illumina offers a broad portfolio of next-generation sequencing (NGS)- and array-based epigenetic analysis tools that provide robust, simple-to-use, and cost-efficient solutions for studying these epigenetic modifications and their impact on gene regulation. By working with leading epigenomics experts, Illumina ensures its solutions meet the field's rapidly evolving needs.
This eBook discusses genomics applications in gene expression and regulation research. See how RNA-Seq and epigenetic methods provide complementary information.
Investigate methylation patterns quantitatively across the genome using sequencing- and array-based techniques.
Learn MoreGain insight into protein–DNA interactions. Investigate the potential impact of chromatin modifications and local structural changes on gene expression.
Learn MoreUse ATAC-Seq to evaluate regions of open chromatin across the genome. ATAC-Seq can be performed on bulk cell populations or single cells at high resolution.
Learn MoreIn this wide-ranging interview, Dr. Kathleen C. Barnes describes her work as a genetic epidemiologist, how COVID-19 impacted her research plans, and how methylation arrays add another dimension to the study of infectious diseases.
Read ArticleResearchers use methylation arrays and NGS to investigate the epigenetics behind cancer metastasis.
Read ArticleResearchers use NGS to study DNA-protein interactions, analyze gene expression, and assess coding exons.
Read ArticleIn plants, chromatin accessibility – the primary mark of regulatory DNA – is relatively static across tissues and conditions. This scarcity of accessible sites that are dynamic or tissue-specific may be due in part to tissue heterogeneity in previous bulk studies.
Join us for this webinar on single-cell ATAC-Seq of Arabidopsis thaliana. The speakers discuss an analytical framework to infer the regulatory networks that govern plant development.
View WebinarStudies of epigenetic alterations in cancer, such as aberrant methylation and transcription factor binding, can provide insight into important tumorigenic pathways. Learn more about epigenetic changes in cancer.
Genome-wide methylation profiling can help researchers understand the mechanisms behind complex diseases. Aberrant methylation has been implicated in complex disorders such as Alzheimer’s disease and asthma. Learn more about complex disease research.
A collection of research papers that systematically characterize epigenomic landscapes in primary human tissues and cells.
Marilee Morgan discusses the use of NGS to correlate epigenetic signatures with brain image scans of substance abusers.
A review of current research into the impact of epigenetics on human health.
A SEPA-funded initiative at the Genetic Science Learning Center at the University of Utah.
An introduction to epigenetics and the role it plays in cancer, genetic disease, and development.
A comprehensive guide on array and sequencing-based methylation methods.
A consortium generating 100 reference epigenomes to understand gene activation and repression in healthy and diseased human cells.
*Data calculations on file. Illumina, Inc., 2017.