NovaSeq 6000Dx instrument applications
Dual modes of operation enable both IVD testing and clinical research, opening new possibilities across a range of sample types, sequencing methods, and applications
TruSight Whole Genome offers an EU IVDR 2017/746-compliant and comprehensive, DNA-to-variant call format (VCF) workflow solution for clinical WGS. Only available in select locations (see availability on product page).
Application note:
Validating TruSight Whole Genome
TruSight Whole Genome Dx Library Prep
PCR-free library preparation reagents with included indexes provide minimal bias and superior coverage uniformity.
Only available in select locations.
Reagents for the NovaSeq 6000Dx provide IVDR-compliant, ready-to-use cartridge-based reagents for cluster generation and SBS.
The DRAGEN server features an integrated FPGA chip for accurate, ultrarapid NGS secondary data analysis with DRAGEN for NovaSeq 6000Dx and a dedicated analysis module for TruSight Whole Genome.
Illumina DNA Prep with Enrichment Dx is a fast, integrated workflow for a wide range of applications. It supports a broad DNA input range and multiple sample types including blood, genomic DNA, and formalin-fixed, paraffin-embedded (FFPE) tissue..
Application note:
Target enrichment on the NovaSeq 6000Dx Instrument
Illumina DNA Prep with Enrichment Dx
This IVDR-compliant solution enables clinical laboratories to add targeted enrichment panels to their menu of diagnostic applications.
Reagents for the NovaSeq 6000Dx provide IVDR-compliant, ready-to-use cartridge-based reagents for cluster generation and SBS.
The DRAGEN server features an integrated FPGA chip for accurate, ultrarapid NGS secondary data analysis with DRAGEN for NovaSeq 6000Dx and a dedicated analysis module for Illumina DNA Prep with Enrichment Dx.
A high-performing, fast, and integrated workflow for sensitive applications such as human whole-genome sequencing.
A fast, integrated workflow for a wide range of applications, from human whole-genome sequencing to amplicons, plasmids, and microbial species.
Generate whole-genome sequencing libraries and efficiently interrogate samples with limited available DNA.
Simple, all-inclusive whole-genome sequencing (WGS) library preparation that provides accurate and comprehensive coverage of complex genomes.
Reagent kits for the NovaSeq 6000 provide ready-to-use cartridge-based reagents for cluster generation and SBS. NovaSeq 6000Dx is compatible with RUO reagent kits in research mode.
The DRAGEN Germline with features integrated FPGA chip for accurate ultra rapid NGS secondary analysis with DRAGEN for NovaSeq 6000Dx in Research Mode.
Leverage DRAGEN Germline or DRAGEN Somatic on Illumina BaseSpace Sequence Hub, or stand-alone DRAGEN server (purchased separately) for accurate, comprehensive, and efficient secondary analysis.
Utilize the NovaSeq 6000Dx DRAGEN server in RUO mode to convert BCL files to FASTQ.
Use converted FASTQ files as the input to any custom secondary analysis for fewer user touchpoints and improved workflow efficiency.
Reduce storage and operational costs by up to 5x with lossless FASTQ ORA compression.
Illumina DNA Prep with Enrichment
A fast, integrated workflow for a wide range of applications providing targeted resequencing for custom panels, fixed panels, and whole-exome enrichment.
Illumina DNA Prep with Exome 2.5 Enrichment
A high-performance, fast, and complete whole-exome sequencing kit.
Reagent kits for the NovaSeq 6000 provide ready-to-use cartridge-based reagents for cluster generation and SBS. NovaSeq 6000Dx is compatible with RUO reagent kits in research mode.
Paired DRAGEN server for NovaSeq 6000Dx
Leverage the Illumina DRAGEN for Illumina DNA Prep with Enrichment (IDPE) App in RUO mode for accurate and efficient secondary analysis.
BCL Convert
Utilize the NovaSeq 6000Dx DRAGEN server in RUO mode to convert BCL files to FASTQ.
Use converted FASTQ files as the input to any custom secondary analysis for fewer user touchpoints and improved workflow efficiency.
Reduce storage and operational costs by up to 5x with lossless FASTQ ORA compression.
TruSight Oncology 500 High-Throughput (HT)
TruSight Oncology 500 HT enables in-house comprehensive genomic profiling of tumor samples with flexibility for higher sample throughput and batching options. DNA & RNA content targets 523 genes for assessment of all DNA and RNA variant types, plus TMB and MSI. Automation kits and methods are available for reduced hands-on time and scalability.
Flexible sample batching allows for 16-192 samples per sequencing flow cell on the NovaSeq 6000Dx system, in RUO mode. Reagent kits for the NovaSeq 6000 provide ready-to-use cartridge-based reagents for cluster generation and SBS. NovaSeq 6000Dx is compatible with RUO reagent kits when used in research mode.
Stand-alone DRAGEN server or Illumina Connected Analytics (ICA)
Rapid variant calling algorithm powered by DRAGEN pipelines, available locally with separate, stand-alone DRAGEN server. Secure, scalable, cloud-based variant calling is also available with DRAGEN pipelines on Illumina Connected Analytics (ICA), featuring auto-launch capability.
The NovaSeq 6000Dx instrument is intended for targeted sequencing of DNA libraries from human genomic DNA extracted from peripheral whole blood or formalin-fixed, paraffin-embedded (FFPE) tissue when used with in vitro (IVD) diagnostic assays. The NovaSeq 6000Dx instrument is not intended for whole-genome or de novo sequencing. The NovaSeq 6000Dx instrument is intended for use with specific registered, certified, or approved IVD reagents and analytical software.
The NovaSeq 6000Dx instrument is intended for sequencing of DNA libraries when used with in vitro diagnostic (IVD) assays. The NovaSeq 6000Dx instrument is intended for use with specific registered, certified, or approved IVD reagents and analytical software.