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Infinium Global Screening Array with Cytogenetics-24 | Genotyping array

Infinium Global Screening Array with Cytogenetics-24

Detect structural variation in the human genome and examine cytogenomic changes in constitutional diseases and cancers with this research microarray.

Overview

The Infinium Global Screening Array-24 with Cytogenetics-24 contains approximately 700K variants, including 80K supplemental probes targeting more than 4800 tiered genes and regions with known disease associations. Target variants were selected based on the input from a cytogenetics research consortium and include genes defined by ClinGen as pathogenic and likely pathogenic along with an enhanced backbone for a modern, up-to-date assay.

  • Detect structural variation in the human genome, including duplications, deletions, amplifications, copy-neutral loss of heterozygosity, and mosaicism

  • Examine cytogenomic changes in constitutional diseases, cancers, and more

  • Process sample types including saliva, blood, and buccal swabs using the polymerase chain reaction (PCR)-free Infinium HTS Assay with only 200 ng DNA per sample

  • Analyze formalin-fixed paraffin-embedded (FFPE) paired tumor-normal samples when used with the appropriate FFPE cluster file

Broad clinical research applications

Markers were selected from clinical research databases, including ClinVar, CPIC, and PharmGKB for research applications, including risk profiling, pharmacogenomics, wellness characterization, and disease discovery.

Specifications

Assay time 3 days
Automation capability Automated array loader, Liquid handling robot(s)
Cancer type Hematologic, Solid tumor
Description The 24-sample Infinium Global Screening Array with Cytogenetics-24 provides targeted coverage of more than 4800 key genes across the genome. Approximately 700K markers are included on the BeadChip for high exonic coverage in regions of disease relevance, providing highly accurate copy number variation calls, and an average resolution of 2.5Mb.
Hands-on time 1 hour and 5 minutes for automated 8-beadchip workflow
Input quantity 200 ng DNA
Instruments iScan System
Method Cytogenomic array, High-throughput genotyping array
Nucleic acid type DNA
Number of samples 24 samples per array
Specialized sample types Blood, FFPE tissue, Buccal swabs, Saliva
Species category Human
Technology Microarray
Variant class Single nucleotide polymorphisms (SNPs), Loss of heterozygosity (LOH), Chromosomal abnormalities, Copy number variants (CNVs)

Applications

Example workflow

1
Select content

Infinium Global Screening Array with Cytogenetics-24

2
Process and scan
3
Track, analyze and report
BioDiscovery NxClinical

Related applications and methods

Chromosomal microarray analysis

Chromosomal microarrays reliably detect copy number and allelic contribution imbalances associated with constitutional disorders.

Cytogenomics

Together, next-generation sequencing and arrays enable cytogenomic analysis of chromosome aberrations for constitutional and cancer research.

Copy number variation analysis

Perform high-resolution copy number variation (CNV) analysis with Illumina array and next-generation sequencing solutions.

Documentation

Product literature
Support documentation

Compare

Infinium Global Screening Array with Cytogenetics-24 Infinium Global Diversity Array with Cytogenetics-8
Assay time 3 days 3 days
Automation capability Automated array loader, Liquid handling robot(s) Automated array loader, Liquid handling robot(s)
Cancer type Hematologic, Solid tumor Hematologic, Solid tumor
Description The 24-sample Infinium Global Screening Array with Cytogenetics-24 provides targeted coverage of more than 4800 key genes across the genome. Approximately 700K markers are included on the BeadChip for high exonic coverage in regions of disease relevance, providing highly accurate copy number variation calls, and an average resolution of 2.5Mb. The 8-sample Infinium Global Diversity Array with Cytogenetics-8 provides extensive targeted coverage of more than 4800 key genes across the genome. Approximately 1.8M markers are included on the BeadChip for high exonic coverage in regions of disease relevance, providing highly accurate copy number variation calls, and an average resolution of 1.5Mb.
Hands-on time 1 hour and 5 minutes for automated 8-beadchip workflow 1 hour and 5 minutes for automated 8-beadchip workflow
Input quantity 200 ng DNA 200 ng DNA
Instruments iScan System iScan System
Nucleic acid type DNA DNA
Number of samples 24 samples per array 8 samples per array
Specialized sample types Blood, FFPE tissue, Buccal swabs, Saliva Blood, FFPE tissue, Buccal swabs, Saliva
Species category Human Human
Technology Microarray Microarray
Variant class Single nucleotide polymorphisms (SNPs), Loss of heterozygosity (LOH), Chromosomal abnormalities, Copy number variants (CNVs) Single nucleotide polymorphisms (SNPs), Loss of heterozygosity (LOH), Chromosomal abnormalities, Copy number variants (CNVs)

Infinium Global Screening Array with Cytogenetics (24 Samples)

20122862

The Infinium Global Screening Array with Cytogenetics-24, 24 Samples Kit combines a versatile genome-wide backbone with optimized content for advanced cytogenetic analysis. Each BeadChip assays ~700K total variants. The kit contains 1 BeadChip and the necessary reagents for amplifying, fragmenting, hybridizing, labeling, and detecting 24 samples.

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Infinium Global Screening Array with Cytogenetics (48 Samples)

20066469

The Infinium Global Screening Array with Cytogenetics-24, 48 Samples Kit combines a versatile genome-wide backbone with optimized content for advanced cytogenetic analysis. Each BeadChip assays ~700K total variants. The kit contains 2 BeadChips and the necessary reagents for amplifying, fragmenting, hybridizing, labeling, and detecting 48 samples.

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Infinium Global Screening Array with Cytogenetics (288 Samples)

20066470

The Infinium Global Screening Array with Cytogenetics-24, 288 Samples Kit combines a versatile genome-wide backbone with optimized content for advanced cytogenetic analysis. Each BeadChip assays ~700K total variants. The kit contains 12 BeadChips and the necessary reagents for amplifying, fragmenting, hybridizing, labeling, and detecting 288 samples.

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Infinium Global Screening Array with Cytogenetics (1152 Samples)

20066471

The Infinium Global Screening Array with Cytogenetics-24, 1152 Samples Kit combines a versatile genome-wide backbone with optimized content for advanced cytogenetic analysis. Each BeadChip assays ~700K total variants. The kit contains 48 BeadChips and the necessary reagents for amplifying, fragmenting, hybridizing, labeling, and detecting 1152 samples.

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Services (1)

Infinium® Assay: An Introduction – Customer Site

20015273

Three-day, hands-on instruction at customer site to familiarize users with the essential steps in the Infinium protocol. Course provides hands-on training in sample and BeadChip preparation, sample scanning using the iScan System, and primary data evaluation and analysis using array analysis software.

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