TruSight Oncology 500 Report
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Illumina Connected Insights
Streamline precision oncology research
Comprehensive insights and automation to support somatic oncology variant interpretation and research reporting for any assay, at any scale*
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*Illumina Connected Insights is only available in select countries and regions. If you are interested in data analysis solutions, please contact us to learn about available options for your country.
Precision-engineered variant interpretation and reporting for oncology
Illumina Connected Insights is a powerful software enabling AI-assisted variant interpretation and reporting of next-generation sequencing (NGS) data. Harnessing globally-recognized knowledge sources and ingesting data from a wide range of oncology assays, Connected Insights is precision-engineered to enhance accuracy of results and accelerate reporting.
Streamlined
Unify your knowledge sources in one powerful solution and streamline interpretation with customizable automation. Reduce your variant review lists by up to 90%.*
Integrated
Remove unnecessary touchpoints and move from sequencing through draft report faster. Seamless compatibility with Illumina assays, instruments, and software, including DRAGEN—winner of the FDA Truth Challenge.1
Powered for growth
Keep pace with the latest science and future-proof your lab. Ingest data from any assay, at any scale. Access the latest innovations in variant calling, Illumina proprietary AI algorithms, and visualizations.
We help you achieve
Powerful insights
Generate insights from 55+ knowledge sources including the Clinical Knowledgebase (CKB) from Genomenon, CiVIC, and OncoKB. Prioritize relevant clinical trials, drug labels, and guidelines within a single environment.
Interactive visualizations
Generate gene- and exon-level visualizations for DNA and RNA, variant QC, genome plots for structural variants, Circos plots, B-allele ratio, fusion plots, and more.
Automation
From data upload, automated guidelines-based oncogenicity classification, to report generation – configure your settings and automate for a streamlined experience with minimum touchpoints.
Future-proofing
Evolve with confidence across assays and applications—from panels to genomes and transcriptomes, from tissue to liquid biopsy and heme.
Regionality
Configure regional content, preferences and language to meet regional needs.
Security
Employ security-first infrastructure and conform to privacy and compliance software requirements and regulations.
Key applications
DNA variants
Identify key DNA variant types (SVs, MNVs, exon-level CNVs, indels, fusions, tandem repeats, LOH) relevant in multiple disease types and across a variety of NGS assays.
RNA variants
Analyze variants from RNA or transcriptomics (fusions, splice variants, and soon expression levels) to gain a deeper and more comprehensive understanding of malignancies.
Biomarker signatures
Uncover more insights by interpreting genome- wide pan-cancer biomarker signatures (TMB, MSI, HRD) with increasing relevance to precision medicine.
Software preview
Powerful visualizations
Deepen your insights with cutting-edge visualizations and explore genome view, DNA and RNA coverage plots, variant allele frequency (VAF), fusion plots, and more.
Automated oncogenicity prediction
Leverage proprietary Illumina AI algorithms and pull from a comprehensive set of sources (including previously curated variants) as predictors to automatically calculate the oncogenicity classification score of relevant variants.
Heme Subtype Autoclassification
Automatically detect hematological cancer subtypes based on key guidelines, leveraging interactive evidence maps and automated report summaries.
Product content
Illumina Connected Insights data sheet
Read how Connected Insights streamlines, integrates, and powers molecular laboratories for scale and growth.
Discover how Connected Insights can streamline user-defined variant interpretation research workflows and reduce to research report, all within a single environment.
Connected Insights security brief
Learn how Connected Insights employs key security and privacy features to protect sensitive NGS data.
NGS workflow with Illumina Connected Insights
Prep
Prepare libraries for somatic oncology panels, CGP, or other compatible applications.
Sequence
Sequence libraries using any Illumina or other sequencing platform.
Analyze
Call variants with DRAGEN or other secondary analysis tools to generate VCF (Variant Call Format) output.
Interpret
Ingest VCF files to Connected Insights to enable generation of insights and case reporting.
Flexible deployment options
Variant interpretation within a secure cloud ecosystem
Directly integrated within the Illumina Connected Software ecosystem, Connected Insights on the cloud unifies highly scalable data management and processing with an enterprise-level data privacy and security all within a single environment. A direct integration option with DRAGEN for variant calling is seamless and automated.
Variant interpretation on-premises
Accessed via a DRAGEN server, Connected Insights-Local supports customers in environments where access to the cloud is not an option. Connected Insights on-premises allows users to directly pair DRAGEN with Connected Insights, offering a solution for local somatic oncology variant calling and interpretation.
Read about the joint power of DRAGEN and Connected Insights-Local:
Illumina Connected Insights
Streamline tertiary analysis, from data upload to research report generation, for oncology applications and beyond using Illumina Connected Insights-Research. Connected Insights-Research is a customizable tertiary analysis platform enabling clinical research labs to keep pace with new knowledge, expand test menus, and scale for precision medicine.
The Jackson Laboratory advances precision medicine with an end-to-end workflow
The Jackson Laboratory scales their genetic discovery and molecular profiling services for cancer neurogenomics, adopting Illumina Connected Insights as part of an end-to-end Illumina informatics workflow.
Built for speed, transparency, and scalability, Illumina Connected Insights integrates over 55 curated databases, AI-driven tools like SpliceAI and PrimateAI-3D, and delivers case summaries aligned with clinical guidelines—empowering labs to move from raw data to meaningful answers with confidence.
Updates: hear the latest
View the software resources page for the latest release information and other news.
Simple pricing that grows with you
Try the complete BioInsight Platform free for 30 days with no credit card, no purchase order, and no obligations. When you're ready to scale, pay only for what you use or choose the option to save with volume discounts.
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Perfect for: Variable workloads and usage
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Enable CGP with a large pan-cancer panel covering all main variant classes plus key biomarkers (TMB, MSI, and HRD) from FFPE tissue.
Try Illumina Connected Insights for free
Discuss your workflow to learn how you can streamline your NGS operations and power your lab for growth using Illumina Connected Insights. Start a free trial with no credit card required.
References
- Precision FDA Truth Challenge v2 https://precision.fda.gov/challenges/10