The DRAGEN Platform can process NGS data for an entire human genome at 30× coverage in about 25 minutes on premise vs. > 15 hours with a traditional CPU-based system. It set two world speed records for genomic data analysis.2,3
The DRAGEN Platform can reduce on-premise investments in server clusters and utilization of cloud computing resources.
In the 2018 PrecisionFDA Hidden Treasures – Warm Up Challenge, The DRAGEN Platform received the highest score in five out of six accuracy measures for whole-genome variant calling among platforms that recognized all 50 variants.1
The DRAGEN Platform analyzes sequencing data from whole genomes, whole exomes, germline and somatic datasets, and RNA sequencing experiments.
Frequent releases continuously expand and improve the DRAGEN Platform while accommodating new applications and addressing evolving industry standards.
The DRAGEN Platform enables labs of all sizes and disciplines to do more with their genomic data. The DRAGEN Platform uses highly reconfigurable field-programmable gate array technology (FPGA) to provide hardware-accelerated implementations of genomic analysis algorithms, such as BCL conversion, mapping, alignment, sorting, duplicate marking, and haplotype variant calling. Fundamental features of the DRAGEN Platform address common challenges in genomic analysis, such as lengthy compute times and massive volumes of data.
Without compromising accuracy, the DRAGEN Platform delivers quickness, flexibility, and cost efficiency. The reprogrammable nature of the DRAGEN Platform enables Illumina to develop custom algorithms and allows for improvements to accommodate future applications.
DRAGEN on BaseSpace Sequence Hub couples speed and accuracy of the DRAGEN Platform with the security, cost savings, and intuitive interface of BaseSpace Sequence Hub.
DRAGEN on-premise conducts secondary analysis in a fraction of the time compared with a traditional CPU-based system, while still maintaining high accuracy.
Name |
Description |
Availability |
|---|---|---|
| Illumina DRAGEN Germline Pipeline | The DRAGEN Germline Pipeline provides end-to-end (BCL ➝ VCF) NGS analysis, including advanced error model calibration for increased accuracy, and repeat expansion detection and genotyping through Illumina Expansion Hunter. | On-Premise On BaseSpace Sequence Hub |
| Illumina DRAGEN Somatic Pipeline | The DRAGEN Somatic Pipeline includes tumor-only and tumor–normal modes, designed for detecting somatic variants in tumor samples | On-Premise On BaseSpace Sequence Hub |
| DRAGEN Reference Builder | This app accepts FASTA files, and builds the proprietary reference used by the DRAGEN apps. | On-Premise On BaseSpace Sequence Hub |
| Illumina DRAGEN RNA Pipeline | The DRAGEN RNA Pipeline performs transcriptome analysis starting with splice junction discovery and alignment, followed by rapid alignment and splice junction mapping, quantification, and fusion detection. | On-Premise Coming soon on BaseSpace Sequence Hub |
| Illumina DRAGEN Joint Genotyping/Population Pipeline | The DRAGEN Joint Genotyping/Population Pipeline calls variants jointly across multiple genomes and scales to large cohorts of samples at expedited speeds with uncompromising accuracy. | On-Premise On BaseSpace Sequence Hub |
| Illumina DRAGEN CNV Pipeline | The DRAGEN CNV Pipeline performs copy number variant (CNV) analysis for germline and somatic exomes and genomes. Various levels of filtering can be applied to mitigate false positives before emitting the final calls. | On-Premise On BaseSpace Sequence Hub |
| Illumina DRAGEN Methylation Pipeline | The DRAGEN Methylation Pipeline offers multiple operating modes, including reference-only alignment and annotation-assisted. | On-Premise On BaseSpace Sequence Hub |
| Illumina DRAGEN Map + Align Pipeline | The DRAGEN Map + Align pipeline is capable of ultra-rapid mapping and aligning DNA and RNA for both exomes and genomes. | On-Premise On BaseSpace Sequence Hub |
Collaborators Anthony Philippakis from The Broad Institute, and Susan Tousi of Illumina, discuss how integration of GATK with Illumina sequencers and implementation of the DRAGEN Platform may facilitate hardware acceleration and standardization of data analysis.
View VideoLeveraging DRAGEN, GeneDx is now able to grow its operations while keeping costs low, turnaround times short, and accuracy high.
Read ArticleA Guinness world record was set for Fastest Genetic Diagnosis in 19.5 hours. The DRAGEN Platform was used to significantly increase the speed of mapping and aligning genomic data once sequenced.1
Read ArticleIn the 2018 PrecisionFDA Hidden Treasures – Warm Up Challenge, The DRAGEN Platform received the highest score in five out of six accuracy measures for whole-genome variant calling among platforms that recognized all 50 variants.2
Read ArticleThe DRAGEN Platform can be used for numerous applications in the biological sciences.
Rapidly analyze the sequenced genomes; accelerate reanalysis as computational tools improve over time.
Reduce time required for genomic analysis, when fast results can be a critical factor.
Accurate, rapid analysis of tumor-only and tumor/normal samples.
Analyze animals and plants of varying genomic complexities, using a provided reference.
Analyze targeted exome data with rapid turnaround and high accuracy to ensure reproducibility and high-quality results.
DRAGEN provides the flexibility to insert a variety of input files and produce a range of output documents. This flexibility enables users to customize their experience and use and produce their desired file format.
This diagram shows steps in the DRAGEN Germline Pipeline as an example. The actual steps vary for each pipeline.
DRAGEN Accuracy Application Note
Application Note | HTML
BaseSpace Sequence Hub Quick Apps Handout
Brochure | PDF< 1 MB
Benefits of whole-genome sequencing
Brochure | PDF< 1 MB
DRAGEN Bio-IT Platform on BaseSpace Sequence Hub
Data Sheet | PDF1 MB
DRAGEN Germline Pipeline Specification Sheet
Data Sheet | HTML
Data Sheet | HTML
Simplify your bioinformatics with an economical and powerful computing environment to manage, analyze, and share data.
BaseSpace Variant Interpreter enables genetic labs to rapidly identify biologically significant variants from human genomic data.
BaseSpace Correlation Engine mines over 20,000 genomic studies to get data-driven answers for genes, experiments, drugs and phenotypes for your research.
