DRAGEN v3.8 released March 2021 | New features include:
The Illumina DRAGEN Bio-IT platform and data submission apps on BaseSpace Sequence Hub also support the SARS-CoV-2 Data Toolkit. Learn More.
DRAGEN on BaseSpace Sequence Hub
DRAGEN on Illumina Connected Analytics
DRAGEN On-Premise
DRAGEN on NextSeq 1000/2000
The DRAGEN Platform can process NGS data for an entire human genome at 30× coverage in about 25 minutes on premise vs. > 15 hours with a traditional CPU-based system. It set two world speed records for genomic data analysis.2,3
When run on Illumina's BaseSpace Sequence Hub or Illumina Connected Analytics, analysis for a 30x genome is ~$5/sample and an exome at 100x coverage ~$3/sample.
In the 2020 PrecisionFDA Truth Challenge V2, DRAGEN won Difficult to Map Regions and All Benchmark Regions on Illumina Sequencing data.1
The DRAGEN Platform analyzes sequencing data from a variety of experiment types, including whole genomes, whole exomes, germline and somatic datasets, and RNA sequencing experiments.
DRAGEN ORA (Original Read Archive) compression technology is optimized for high compression ratios of FASTQ files, as well as rapid compression and decompression, all while preserving data integrity.
Frequent releases continuously expand and improve the DRAGEN Platform while accommodating new applications and addressing evolving industry standards. DRAGEN updates are version controlled, enabling users to opt in or out of new updates as desired.
The DRAGEN team at Illumina is excited to announce winning Best Performance in the Difficult to Map Regions and All Benchmark Regions on Illumina Sequencing data. This win marks the start of major new capabilities that will be improved to include structural variants, copy number variations, and repeat expansions. Our success shows that we can now call variants with better accuracy than what was thought possible in difficult to map regions.
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The DRAGEN Platform enables labs of all sizes and disciplines to do more with their genomic data. The DRAGEN Platform uses highly reconfigurable field-programmable gate array technology (FPGA) to provide hardware-accelerated implementations of genomic analysis algorithms, such as BCL conversion, mapping, alignment, sorting, duplicate marking, and haplotype variant calling. DRAGEN ORA lossless genomic compression technology enables significant storage cost savings on FASTQ files. Fundamental features of the DRAGEN Platform address common challenges in genomic analysis, such as lengthy compute times and massive volumes of data.
Without compromising accuracy, the DRAGEN Platform delivers quickness, flexibility, and cost efficiency. The reprogrammable nature of the DRAGEN Platform enables Illumina to develop custom algorithms and allows for improvements to accommodate future applications.
| DRAGEN server | BaseSpace | Illumina Connected Analytics | NextSeq 1000/2000 | |
|---|---|---|---|---|
| Demultiplexing (BCL Convert) | ||||
| DRAGEN ORA lossless genomic compression | ||||
| Map & Align | ||||
| Whole genome (germline & somatic) | Germline only | |||
| Exome enrichment (germline & somatic) | ||||
| COVIDSeq | ||||
| RNA Pathogen Detection | ||||
| RNA-Seq (gene fusion & quantification) | ||||
| Single-Cell RNA | ||||
| Joint Genotyping | ||||
| Methylation | ||||
| TSO 500 Liquid | ||||
| Metagenomics |
DRAGEN is also available via an Amazon Machine Image (AMI) on AWS MarketPlace
Alexander Bisignano, cofounder and Chief Executive Officer of Phosphorus, discusses how the company uses the DRAGEN Bio-IT Platform to perform genomics data analysis onsite and at an accessible price point.
Read Interview
Illumina is making it simpler for researchers to detect and identify SARS-CoV-2 and contribute their findings to the community with an integrated software toolkit, free of charge.
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DRAGEN on BaseSpace Sequence Hub or Illumina Connected Analytics couples the speed and accuracy of the DRAGEN platform with the security, cost savings, and intuitive interface of our software platforms.
DRAGEN on-premise conducts secondary analysis in a fraction of the time compared with a traditional CPU-based system, while still maintaining high accuracy.
The on-board DRAGEN Bio-IT Platform offers an ultra-rapid, accurate solution for secondary analysis.
Collaborators Anthony Philippakis from The Broad Institute, and Susan Tousi of Illumina, discuss how integration of GATK with Illumina sequencers and implementation of the DRAGEN Platform may facilitate hardware acceleration and standardization of data analysis.
View VideoLeveraging DRAGEN, GeneDx is now able to grow its operations while keeping costs low, turnaround times short, and accuracy high.
Read ArticleA Guinness world record was set for Fastest Genetic Diagnosis in 19.5 hours. The DRAGEN Platform was used to significantly increase the speed of mapping and aligning genomic data once sequenced.1
Read ArticleSee how Basespace Sequence Hub and DRAGEN have simplified NGS data analysis for this lab.
Read ArticleThe DRAGEN Platform can be used for numerous applications in the biological sciences.
Rapidly analyze the sequenced genomes; accelerate reanalysis as computational tools improve over time.
Reduce time required for genomic analysis, when fast results can be a critical factor.
Accurate, rapid analysis of tumor-only and tumor/normal samples.
Analyze animals and plants of varying genomic complexities, using a provided reference.
Analyze targeted exome data with rapid turnaround and high accuracy to ensure reproducibility and high-quality results.
DRAGEN provides the flexibility to insert a variety of input files and produce a range of output documents. This flexibility enables users to customize their experience and use and produce their desired file format.
This diagram shows steps in the DRAGEN Germline Pipeline as an example. The actual steps vary for each pipeline.
Integrating the Illumina DRAGEN Bio-IT Platform within your Infrastructure
Technical Note | PDF< 1 MB
Tumor exome sequencing with Illumina DNA Prep with Enrichment and the DRAGEN Platform
Application Note | PDF1 MB
Application Note | HTML | 5 versions
Basespace Sequencing Hub Apps Quick Guide
Brochure | PDF< 1 MB
DRAGEN Bio-IT Platform on BaseSpace Sequence Hub
Data Sheet | PDF1 MB
DRAGEN Germline Pipeline Specification Sheet
Data Sheet | HTML
Data Sheet | PDF | 5 versions
Data management and simplified bioinformatics for labs getting started and for rapidly scaling next-generation sequencing (NGS) operations.
A modular, secure data platform for scalable multi-omics data management, analysis, and exploration, to discover insights that unlock the power of the genome.
BaseSpace Correlation Engine mines over 23,000 (and growing) scientific studies to get data-driven answers for genes, experiments, drugs and phenotypes for your research.
