Illumina DRAGEN Bio-IT Platform

The Illumina DRAGEN (Dynamic Read Analysis for GENomics) Bio-IT Platform provides accurate, ultra-rapid secondary analysis of sequencing data. Read More...
The Illumina DRAGEN Bio-IT Platform offers
  • Accurate data: Detects small variants with high analytical sensitivity and specificity1
  • Robust speed: Processes an entire human genome at 30× coverage in about 25 minutes2,3
  • Frequent releases: Includes releases of regular enhancements and upgrades
  • Various applications: Analyzes next-generation sequencing (NGS) data from whole-genome and exome data
DRAGEN Options
DRAGEN on BaseSpace Sequence Hub
DRAGEN on BaseSpace Sequence Hub
DRAGEN On-Premise
DRAGEN On-Premise
Ultra-Rapid Analysis

The DRAGEN Platform can process NGS data for an entire human genome at 30× coverage in about 25 minutes on premise vs. > 15 hours with a traditional CPU-based system. It set two world speed records for genomic data analysis.2,3

Cost-Efficient Solution

The DRAGEN Platform can reduce on-premise investments in server clusters and utilization of cloud computing resources.

Highly Accurate Results

In the 2018 PrecisionFDA Hidden Treasures – Warm Up Challenge, The DRAGEN Platform received the highest score in five out of six accuracy measures for whole-genome variant calling among platforms that recognized all 50 variants.1

Diverse Applications

The DRAGEN Platform analyzes sequencing data from whole genomes, whole exomes, germline and somatic datasets, and RNA sequencing experiments.

Frequent Updates

Frequent releases continuously expand and improve the DRAGEN Platform while accommodating new applications and addressing evolving industry standards.

Illumina and the Broad Institute Partner to Co-develop Secondary Analysis Tools

llumina and the Broad Institute are partnering to co-develop a suite of secondary genomic analysis pipelines. The partnership will result in new methods, integrating Illumina’s DRAGEN™ Pipelines and technology with Broad’s Genome Analysis Toolkit (GATK).

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The DRAGEN Platform enables labs of all sizes and disciplines to do more with their genomic data. The DRAGEN Platform uses highly reconfigurable field-programmable gate array technology (FPGA) to provide hardware-accelerated implementations of genomic analysis algorithms, such as BCL conversion, mapping, alignment, sorting, duplicate marking, and haplotype variant calling. Fundamental features of the DRAGEN Platform address common challenges in genomic analysis, such as lengthy compute times and massive volumes of data.

Without compromising accuracy, the DRAGEN Platform delivers quickness, flexibility, and cost efficiency. The reprogrammable nature of the DRAGEN Platform enables Illumina to develop custom algorithms and allows for improvements to accommodate future applications.

DRAGEN on BaseSpace Sequence Hub couples speed and accuracy of the DRAGEN Platform with the security, cost savings, and intuitive interface of BaseSpace Sequence Hub.

  • Push-button analysis for varying levels of expertise
  • Stream data directly from instruments for rapid analysis
  • Low costs with no hardware investments
  • Leverages the security, compliance, and storage features of BaseSpace Sequence Hub and Amazon Web Services (AWS)

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Learn More About BaseSpace Apps

DRAGEN on BaseSpace Sequence Hub
 

DRAGEN on-premise conducts secondary analysis in a fraction of the time compared with a traditional CPU-based system, while still maintaining high accuracy.

  • Analyze and store data locally
  • Supports varying levels of command line interface
  • Replace up to 30 traditional compute instances
  • Process NGS data for an entire human genome at 30x coverage in < 25 minutes
  • One unit supports two NovaSeq systems running at full capacity

Read Data Sheet

DRAGEN On-Premise

Data Analysis Options

Name

Description

Availability

Illumina DRAGEN Germline Pipeline The DRAGEN Germline Pipeline provides end-to-end (BCL ➝ VCF) NGS analysis, including advanced error model calibration for increased accuracy, and repeat expansion detection and genotyping through Illumina Expansion Hunter.

On-Premise

On BaseSpace Sequence Hub

Illumina DRAGEN Somatic Pipeline The DRAGEN Somatic Pipeline includes tumor-only and tumor–normal modes, designed for detecting somatic variants in tumor samples

On-Premise

On BaseSpace Sequence Hub

DRAGEN Reference Builder This app accepts FASTA files, and builds the proprietary reference used by the DRAGEN apps.

On-Premise

On BaseSpace Sequence Hub

Illumina DRAGEN RNA Pipeline The DRAGEN RNA Pipeline performs transcriptome analysis starting with splice junction discovery and alignment, followed by rapid alignment and splice junction mapping, quantification, and fusion detection.

On-Premise

Coming soon on BaseSpace Sequence Hub

Illumina DRAGEN Joint Genotyping/Population Pipeline The DRAGEN Joint Genotyping/Population Pipeline calls variants jointly across multiple genomes and scales to large cohorts of samples at expedited speeds with uncompromising accuracy.

On-Premise

On BaseSpace Sequence Hub

Illumina DRAGEN CNV Pipeline The DRAGEN CNV Pipeline performs copy number variant (CNV) analysis for germline and somatic exomes and genomes. Various levels of filtering can be applied to mitigate false positives before emitting the final calls.

On-Premise

On BaseSpace Sequence Hub

Illumina DRAGEN Methylation Pipeline The DRAGEN Methylation Pipeline offers multiple operating modes, including reference-only alignment and annotation-assisted.

On-Premise

On BaseSpace Sequence Hub

Illumina DRAGEN Map + Align Pipeline The DRAGEN Map + Align pipeline is capable of ultra-rapid mapping and aligning DNA and RNA for both exomes and genomes.

On-Premise

On BaseSpace Sequence Hub

View Video
The Broad Institute

Collaborators Anthony Philippakis from The Broad Institute, and Susan Tousi of Illumina, discuss how integration of GATK with Illumina sequencers and implementation of the DRAGEN Platform may facilitate hardware acceleration and standardization of data analysis.

View Video

GeneDx Scales from Exomes to Genomes using DRAGEN

Leveraging DRAGEN, GeneDx is now able to grow its operations while keeping costs low, turnaround times short, and accuracy high.

Read Article            
Rady Children’s Hospital

A Guinness world record was set for Fastest Genetic Diagnosis in 19.5 hours. The DRAGEN Platform was used to significantly increase the speed of mapping and aligning genomic data once sequenced.1

Read Article            
PrecisionFDA

In the 2018 PrecisionFDA Hidden Treasures – Warm Up Challenge, The DRAGEN Platform received the highest score in five out of six accuracy measures for whole-genome variant calling among platforms that recognized all 50 variants.2

Read Article            
Population Sequencing

Rapidly analyze the sequenced genomes; accelerate reanalysis as computational tools improve over time.

NICU and Genetic Disease

Reduce time required for genomic analysis, when fast results can be a critical factor.

Cancer Research

Accurate, rapid analysis of tumor-only and tumor/normal samples.

Agrigenomics

Analyze animals and plants of varying genomic complexities, using a provided reference.

Clinical and Translational Research

Analyze targeted exome data with rapid turnaround and high accuracy to ensure reproducibility and high-quality results.

References
  1. Precision FDA Hidden Treasures Warm Up. precision.fda.gov/challenges/1/view/results. Accessed September 14, 2018.
  2. Bio IT World. Children’s Hospital Of Philadelphia, Edico Set World Record For Secondary Analysis Speed. October 23, 2017. www.bio-itworld.com/2017/10/23/childrens-hospital-of-philadelphia-edico-set-world-record-for-secondary-analysis-speed.aspx. Accessed September 19, 2018.
  3. The San Diego Union Tribune. Rady Children's Institute sets Guinness world record. February 12, 2018. www.sandiegouniontribune.com/news/health/sd-no-rady-record-20180209-story.html. Accessed September 19, 2018.

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