DRAGEN v3.10 Updates | New features include:
DRAGEN Azure Lvl 4 1 year License
20060410
The Illumina DRAGEN Bio-IT platform and data submission apps on BaseSpace Sequence Hub also support the SARS-CoV-2 Data Toolkit. Learn More.
DRAGEN on Illumina Connected Analytics
DRAGEN on BaseSpace Sequence Hub
DRAGEN Multi-Cloud Bring Your Own License
DRAGEN on AWS Marketplace
99.83% accuracy score with the Precision FDA Truth Challenge V2 benchmarking data.3
Analyze whole genomes, exomes, methylomes, and transcriptomes with a single platform.
Fully process a 34× whole human genome in ~36 minutes2, Reduce FASTQ file sizes up to 5× with DRAGEN ORA Compression
The DRAGEN team has introduced powerful machine learning (ML) and improved graph genome mapping. These new advancements propel DRAGEN to lead accuracy across all read technologies in all benchmark regions and the MHC region. In this blog, we show the results collected in the PrecisionFDA Truth Challenge V2, compare the latest DRAGEN accuracy against the challenge submissions across all read technologies, and describe the methods used to reach high accuracy levels.
Read Blog
The DRAGEN Platform enables labs of all sizes and disciplines to do more with their genomic data. The DRAGEN Platform uses highly reconfigurable field-programmable gate array technology (FPGA) to provide hardware-accelerated implementations of genomic analysis algorithms, such as BCL conversion, mapping, alignment, sorting, duplicate marking, and haplotype variant calling. DRAGEN ORA lossless genomic compression technology enables significant storage cost savings on FASTQ files. Fundamental features of the DRAGEN Platform address common challenges in genomic analysis, such as lengthy compute times and massive volumes of data.
Without compromising accuracy, the DRAGEN Platform delivers quickness, flexibility, and cost efficiency. The reprogrammable nature of the DRAGEN Platform enables Illumina to develop custom algorithms and allows for improvements to accommodate future applications.
| DRAGEN On-Premise Server | NextSeq 1000/2000 | BaseSpace | Illumina Connected Analytics | Multi-Cloud Bring Your Own License | ||
|---|---|---|---|---|---|---|
| Pre-configured | Build your own | |||||
| BCL Convert | Not recommended on FPGA | |||||
| DRAGEN ORA compression | ||||||
| DRAGEN FASTQC + MultiQC | ||||||
| Whole genome | Germline + Somatic | Germline | Germline + Somatic | Germline + Somatic | Germline + Somatic | Germline + Somatic |
| Enrichment (including Exome) | Germline + Somatic | Germline + Somatic(no CNV) | Germline + Somatic | Germline + Somatic | Germline + Somatic | Germline + Somatic |
| Exome enrichment (germline & somatic) | ||||||
| DNA Amplicon | ||||||
| RNA | ||||||
| Single-Cell RNA | ||||||
| Differential Expression | ||||||
| NanoString GeoMx NGS | ||||||
| RNA Amplicon | Coming soon | |||||
| Methylation | ||||||
| Metagenomics | ||||||
| RNA Pathogen Detection | ||||||
| COVID | COVIDSeq, COVID Lineage | Cloud only COVIDSeq | COVIDSeq, COVID Lineage | COVID Lineage coming soon | COVIDSeq, COVID Lineage | |
| TSO 500 | ctDNA available, Solid Coming soon | ctDNA & Solid Coming soon | ||||
Illumina is making it simpler for researchers to detect and identify SARS-CoV-2 and contribute their findings to the community with an integrated software toolkit, free of charge.
Learn More
DRAGEN on Illumina Connected Analytics (ICA) couples the accuracy and speed of the DRAGEN with the ability to customize analysis pipeline to operationalize informatics on a secure platform.
Learn about Illumina Connected Analytics
DRAGEN on BaseSpace Sequence Hub (BSSH) provides push button analysis capability in an intuitive, easy-to-use interface with compliance, and storage features of BaseSpace Sequence Hub and Amazon Web Services (AWS).
DRAGEN on-premise offers highly accurate secondary analysis in a fraction of time compared with a traditional CPU based system.
The on-board DRAGEN offers an easy to use, accurate, and efficient secondary analysis solution.
DRAGEN on AWS and Azure gives you access to DRAGEN software in a virtual image on your preferred cloud.
DRAGEN-GATK is a new best practices pipeline for secondary analysis of germline small variants, co-developed by the Broad Institute and Illumina. It combines the gold standard open-source GATK algorithms with the accuracy improvements from DRAGEN to ensure labs of all sizes and disciplines have access to high quality genomic analysis.
View Webinar RecordingKyle Retterer, MS, Chief Technology Officer of GeneDx, discusses how their company used Azure to scale their computing and data storage. This evolution brought more data analysis speed, infrastructure security, risk management, and simplicity to their data management.
Read Customer SpotlightAlexander Bisignano, cofounder and Chief Executive Officer of Phosphorus, discusses how the company uses the DRAGEN Bio-IT Platform to perform genomics data analysis onsite, enabling high-quality analysis with a better turnaround time, at an accessible price point.
Read InterviewA rapid workflow with Illumina DNA PCR-Free Prep, NovaSeq 6000, and DRAGEN reduced turnaround time. The DRAGEN Platform was used to significantly increase the speed of mapping and aligning genomic data once sequenced.
Read ArticleSee how BaseSpace Sequence Hub and DRAGEN enabled easy-to-use, efficient workflows for NGS data analysis.
Read ArticleThe DRAGEN Platform can be used for numerous applications in the biological sciences.
Reduce time required for genomic analysis, with high accuracy and comprehensiveness
Accurate, comprehensive, and rapid analysis of tumor-only and tumor/normal samples
Advance understanding of cellular mechanisms with rapid analysis pipelines for bulk and single cell samples
Accurate, rapid, and scalable analysis of the sequenced genomes. Accelerate re-analysis as computational tools improve over time
Efficiently analyze animals and plants of varying genomic complexities with custom reference
DRAGEN provides the flexibility to insert a variety of input files and produce a range of output documents. This flexibility enables users to customize their experience and use and produce their desired file format.
This diagram shows steps in the DRAGEN Germline Pipeline as an example. The actual steps vary for each pipeline.
Integrating the Illumina DRAGEN Bio-IT Platform within your Infrastructure
Technical Note | PDF< 1 MB
Tumor exome sequencing with Illumina DNA Prep with Enrichment and the DRAGEN Platform
Application Note | PDF1 MB
Application Note | HTML | 5 versions
Basespace Sequencing Hub Apps Quick Guide
Brochure | PDF< 1 MB
DRAGEN Bio-IT Platform on BaseSpace Sequence Hub
Data Sheet | PDF1 MB
DRAGEN Germline Pipeline Specification Sheet
Data Sheet | HTML
Explore the transcriptome with single-cell resolution
Technical Note | PDF1 MB
Technical Note | PDF | 3 versions
High-resolution, high-throughput spatial transcriptomics of complex tissues
Application Note | PDF3 MB
Data Sheet | PDF< 1 MB
Data management and simplified bioinformatics for labs getting started and for rapidly scaling next-generation sequencing (NGS) operations.
A secure genomic data platform to operationalize informatics and drive scientific insights.
BaseSpace Correlation Engine mines over 23,000 (and growing) scientific studies to get data-driven answers for genes, experiments, drugs and phenotypes for your research.
