BioInsight Platform

Compare ways to run DRAGEN

Access DRAGEN across cloud, on-premises infrastructure, onboard sequencers, and standard compute environments

Deployment options at a glance

Illumina DRAGEN Server

Ideal for laboratories that require on-premises performance, predictable throughput, and local data processing.

DRAGEN analysis on Illumina managed cloud

Access scalable compute, workflow management, and analysis applications through Illumina cloud platforms.

DRAGEN BYOL: Public and sovereign cloud

Run analysis in supported public, sovereign, or regional cloud environments where your data reside with DRAGEN Bring-Your-Own-License (BYOL).

DRAGEN BYOL: HPC and on-premise standard compute

Run DRAGEN software mode on the infrastructure you already operate, including HPC clusters, on-premises servers, or institution-managed cloud compute.

DRAGEN analysis onboard

Integrated secondary analysis directly on supported Illumina instruments.

Illumina DRAGEN Server

Get fast, highly accurate DRAGEN secondary analysis using dedicated, on-premises, local infrastructure. Maintain control of data while supporting demanding sequencing workflows with predictable FPGA-accelerated performance and throughput.

  • Enable FPGA-accelerated performance with ultra-fast highly accurate secondary analysis in a fraction of the time
  • Complete small variant calling at 40× coverage in ~26 minutes
  • Analyze and stores data locally
  • Leverage high configurability, update frequency, and pipeline options
  • Support large-scale sequencing operations
  • Support data from multiple sequencers via network-attached storage

  • Dedicated DRAGEN infrastructure
  • Local deployment
  • Customer-managed infrastructure

  • Dedicated Illumina DRAGEN Server (2U rack-mount)
  • Facility power, cooling, and networking per site prep guide
  • DRAGEN license
  • Network-attached storage recommended (NFS or CIFS)

/ Results

DRAGEN analysis on Illumina managed cloud

Run DRAGEN without managing compute infrastructure. Illumina managed cloud provides the simplest path to DRAGEN analysis, with access to workflow management and connected informatics capabilities that can scale with research needs.

BioInsight Platform Core

  • Scale compute for large-scale genomic and multiomic workflows
  • Build, customize, and operationalize analysis pipelines with BioInsight Platform Core
  • Manage workflows through an intuitive web interface, with CLI and API access for programmatic and automated workflows
  • Connect DRAGEN results with BioInsight Platform applications through a shared data layer without manual file transfers between steps
  • Access push-button DRAGEN analysis through BaseSpace Sequence Hub
  • Securely store and manage data without local infrastructure

BaseSpace Sequence Hub

  • Access push-button DRAGEN analysis through an intuitive, easy-to-use interface
  • Automatically launch analysis when sequencing runs are complete
  • Securely store and manage sequencing data
  • Enable rapid deployment without local compute infrastructure
  • Support collaborative research with cloud-based access to data and analysis

  • BioInsight Platform Core (formerly Illumina Connected Analytics)
  • BaseSpace Sequence Hub (BSSH)

  • No local infrastructure required
  • Illumina BioInsight Platform account

/ Results

DRAGEN BYOL

Public and sovereign cloud

Run DRAGEN where your data reside while maintaining control of your cloud environment. Bring-Your-Own-License (BYOL) enables public, sovereign, or regional clouds to scale analysis according to your infrastructure, security, and data residency needs. Run in software mode (SW-mode) or with FPGA acceleration where available.

  • Use your DRAGEN license in the cloud account you control with BYOL
  • Run DRAGEN in supported public, sovereign, or regional cloud environments
  • Maintain control over compute resources, security settings, and cloud costs
  • Address data residency requirements by running analysis where data reside
  • Scale analysis across multiple cloud instances or accounts, as permitted under BYOL licensing
  • Access accelerated FPGA pipelines in supported cloud environments
  • Maintain bit-exact concordance with other DRAGEN deployment mode

Public cloud

  • Amazon Web Services (AWS)
  • Microsoft Azure
  • Google Cloud Platform
  • Oracle Cloud Infrastructure (OCI)

Sovereign and regional cloud

  • Sovereign cloud environments
  • Regional cloud providers

  • Account on Illumina BioInsight Platform
  • Supported public or sovereign cloud environment
  • FPGA-enabled cloud instances (where available)
  • DRAGEN BYOL credentials

  1. DRAGEN licensing details
  2. DRAGEN FPGA
  3. DRAGEN SW-mode
/ Results

DRAGEN BYOL

HPC and on-premise standard compute

Run DRAGEN software mode (SW-mode) on the compute infrastructure your organization already operates. Use the full DRAGEN analysis engine on standard compute while maintaining local data control and deployment flexibility.

  • Run the full DRAGEN analytical engine on existing infrastructure
  • Deploy on x86 servers, local research compute environments, HPC clusters, or supported CPU-based cloud instances
  • Maintain local control of data
  • Achieve bit-exact concordance with FPGA-based DRAGEN deployments
  • Expand access to DRAGEN with minimal runtime tradeoffs compared with FPGA-based deployment (~<1.5 hr for 35× WGS on typical 64 vCPU instances*)

  • x86 servers 
  • Local standard compute 
  • Research compute 
environments 
  • High-performance computing (HPC) clusters

  • Illumina BioInsight Platform account
  • Linux operating system
  • Standard x86 compute infrastructure
  • DRAGEN software mode (SW-mode) license
  • DRAGEN BYOL credentials

/ Results

DRAGEN analysis onboard

Streamline sequencing and secondary analysis by running DRAGEN directly on supported Illumina sequencing systems. Reduce data movement and workflow complexity while accelerating the path from sequencing to results.

  • Run secondary analysis without additional compute infrastructure
  • Reduce file transfers and user touchpoints with integrated sequencing and analysis
  • Access pipelines and applications optimized for supported Illumina sequencing systems
  • Run multiple secondary analysis pipelines in parallel on NovaSeq X Series
  • Access versatile analysis options, including single-cell, exome, and RNA analysis on NextSeq 1000 and NextSeq 2000 Systems
  • Generate comprehensive secondary analysis in two hours or less with supported MiSeq i100 Series applications

NovaSeq X Series
  • Run multiple secondary analysis pipelines in parallel
  • Access DRAGEN BCL Convert, Germline, somatic (tumor only), Enrichment, methylation, and RNA pipelines
  • Run up to four simultaneous applications per flow cell in a single run
  • Achieve up to 5× lossless data compression and analysis with supported applications
  • Save on analysis costs, which can exceed the cost of the sequencing system over five years
 
NextSeq 1000 and NextSeq 2000 Systems
  • Integrate sequencing and analysis functions
  • Use versatile analysis pipeline options, including single-cell, exome, and RNA analysis
  • Get started quickly using an easy-to-use graphical interface with fewer touchpoints
  • Generate high-quality analysis with results in as little as two hours
 
MiSeq i100 Series
  • Take advantage of intuitive, ultra-rapid analysis including DRAGEN BCL Convert, DRAGEN Library QC, DRAGEN small WGS, and DRAGEN Microbial Enrichment Plus
  • Generate comprehensive secondary analysis in two hours or less
  • Use a single user touchpoint to get VCF and/or HTML reports with no intermediate file transfers
  • Work within an intuitive interface for non-expert users

  • Supported Illumina sequencing system
  • No additional compute infrastructure required

/ Results

Get started with DRAGEN

Speak with an Illumina specialist about the right deployment option for your lab and workflows.

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