This microarray offers comprehensive, genome-wide coverage of pharmacogenomic (PGx) markers and features a fast, highly scalable automated workflow.
Sample throughput
Number of samples
Number of markers
This microarray is designed for high-throughput pharmacogenomics (PGx) and large-scale genotyping studies. The 24-sample size offers an excellent mix of variant coverage and scalability while featuring:
Genome-wide coverage of variants with established disease associations, relevant PGx markers, and curated exonic content derived from ClinVar, NHGRI, PharmGKB, and ExAC databases.
Infinium EX format is compatible with the Infinium Amplification System and the Infinium Automated Pipetting System with ILASS to enable a scalable 2.5-day workflow.
DRAGEN Array secondary analysis enables accurate, comprehensive, and efficient CNV calling and star allele annotation.
| Assay type | Infinium EX |
|---|---|
| Automation capability | Liquid handling robot(s) |
| Input quantity | 200 ng |
| Instruments | iScan System |
| Method | High-throughput genotyping array, Genome-wide genotyping array |
| Nucleic acid type | DNA |
| Number of markers | 1,185,155 markers with 10,000 custom marker capacity |
| Number of samples | 24 samples per array |
| Sample throughput | 5,760 samples/week max throughput per iScan System. Throughput and scan times will vary based on system configuration. |
| Specialized sample types | Blood |
| Species category | Human |
| Technology | Microarray |
| Variant class | Single nucleotide polymorphisms (SNPs), Structural variants, Single nucleotide variants (SNVs), Insertions-deletions (indels), Copy number variants (CNVs) |
The main difference between each Infinium Global Clinical Research Array with Enhanced PGx-24 Kit is the number of samples supported with the provided reagents. Select from kits with a “+” designation when custom content is needed for the array.
Customers will need the iScan System, Infinium Automated Pipetting System with ILASS, and an Infinium EX/XT Starter Kit 220V or Infinium EX/XT Starter Kit 110V.
The Infinium Amplification System is optional but can be added to enable automation of the pre-amplification steps in the workflow.
Powerful array for genome-wide pharmacogenomics markers. This tool also supports clinical research and molecular blood typing studies with diverse and underrepresented groups.
Infinium Global Clinical Research Array with Enhanced PGx
DesignStudio is a web-based assay design tool to help researchers design and order custom genotyping microarray probes or custom sequencing assays.
The iScan microarray scanner supports high-throughput BeadChip processing, scanning hundreds to thousands of samples quickly and accurately.
Infinium Automated Pipetting System
Automation options with robot control software for Infinium assays streamline sample preparation workflows and reduce errors.
Automation options with robot control software for Infinium assays streamline sample preparation workflows and reduce errors.
DRAGEN Array provides accurate, comprehensive and efficient secondary analysis for Infinium microarrays.
Understand how variations in the human genome affect our response to medications
Pharmacogenomics, the study of how variations in the human genome affect our response to medications, may help reduce adverse drug reactions and medical costs.
| Infinium Global Clinical Research Array with Enhanced PGx-24 v1.0 Kit | Infinium Global Clinical Research Array-24 v1.0 Kit | Infinium Global Screening Array with Enhanced PGx-48 v4.0 Kit | Infinium Global Diversity Array with Enhanced PGx | |
|---|---|---|---|---|
| Assay type | Infinium EX | Infinium EX | Infinium EX | Infinium LCG |
| Automation capability | Liquid handling robot(s) | Automated array loader, Liquid handling robot(s) | Automated array loader, Liquid handling robot(s) | Automated array loader, Liquid handling robot(s) |
| Input quantity | 200 ng | 100 ng | 200 ng | 200 ng |
| Instruments | iScan System | iScan System | iScan System | iScan System |
| Method | High-throughput genotyping array, Genome-wide genotyping array | High-throughput genotyping array, Genome-wide genotyping array | Genome-wide genotyping array | |
| Nucleic acid type | DNA | DNA | DNA | DNA |
| Number of markers | 1,185,155 markers with 10,000 custom marker capacity | Fixed markers: 1,157,992, Custom marker add-on capacity: Up to 50,000 | 656,275 markers and 10,000 custom marker capacity | 1,933,117 markers in total; custom add-on capacity of 125K |
| Number of samples | 24 samples per array | 24 samples per array | 48 samples per array | 8 samples per array |
| Sample throughput | 5,760 samples/week max throughput per iScan System. Throughput and scan times will vary based on system configuration. | 5760 samples per week | 11,520 samples/week max throughput per iScan System. Throughput and scan times will vary based on system configuration | 1728 samples per week |
| Specialized sample types | Blood | Blood | Blood | Blood |
| Species category | Human | Human | Human | Human |
| Technology | Microarray | Microarray | Microarray | Microarray |
Library Prep and Array Kit Selector
Find the right sequencing library preparation kit or microarray for your needs. Filter by method, species, and more. Compare, share, and order kits.
Clinical research content developed from an extensive list of pharmacogenomics markers selected based on CPIC guidelines and the PharmGKb database.1,2 Content includes variants annotated in PharmGKb, genome-wide PGx coverage, extended AdMe genes,3 CPIC level A genes, and targeted imputation tag SNPs.
The Infinium Global Clinical Research Array with Enhanced PGx-24 v1.0 includes extensive coverage of phenotypes and disease classifications based on nhGRI GwAs database categories.
Variants cover a range of pathogenic and nonpathogenic evidence.
Expertly selected clinical research content from key databases supports a broad range of applications.
The Infinium Global Clinical Research Array with enhanced PGx-24 v1.0 contains ~9K markers enabling various sample tracking functions such as sex determination, continental ancestry, human linkage, and more.
References
Infinium Global Clinical Research Array with Enhanced PGx-24 v1.0 Kit (24 samples)
20065216
Includes one, 24-sample BeadChip and reagents for amplifying, fragmenting, hybridizing, labeling, and detecting 24 DNA samples. Requires 200 ng DNA for input. Each kit is processed as a single batch.
List Price:
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Infinium Global Clinical Research Array with Enhanced PGx-24 v1.0 Kit (96 samples)
20068339
Includes four, 24-sample BeadChips and reagents for amplifying, fragmenting, hybridizing, labeling, and detecting 96 DNA samples. Requires 200 ng DNA for input. Each kit is processed as a single batch.
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Infinium Global Clinical Research Array with Enhanced PGx-24 v1.0 Kit (1152 samples)
20068340
Includes 48, 24-sample BeadChips and reagents for amplifying, fragmenting, hybridizing, labeling, and detecting 1152 DNA samples. Requires 200 ng DNA for input. Each kit is processed as a single batch.
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Infinium Global Clinical Research Array with Enhanced PGx-24+ v1.0 Kit (24 samples)
20068354
Infinium Global Clinical Research Array with Enhanced PGx-24+ v1.0 Kit (24 samples)
Infinium Global Clinical Research Array with Enhanced PGx-24+ v1.0 Kit (96 samples)
20068355
Infinium Global Clinical Research Array with Enhanced PGx-24+ v1.0 Kit (96 samples)
Infinium Global Clinical Research Array with Enhanced PGx-24+ v1.0 Kit (1152 samples)
20068356
Infinium Global Clinical Research Array with Enhanced PGx-24+ v1.0 Kit (1152 samples)
DRAGEN Array Local - star allele annotation
20109885
Per sample analysis quota for star allele calling using DRAGEN Array Local. One per sample analysis quota is needed per sample analyzed for star allele calling using the star-allele call subcommand. DRAGEN Array Local is a command-line software with no FPGA hardware or specialized server required and is downloadable from the Illumina Support Site. Internet is required for per sample quota check.
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DRAGEN Array Cloud - star allele annotation
20109886
Per sample analysis quota for star allele calling using DRAGEN Array Cloud. One per sample analysis quota is needed per sample analyzed for star allele calling using the analysis type, DRAGEN Array – PGx – star allele calling. DRAGEN Array Cloud provides analysis kickoff using BaseSpace Sequence Hub. The BaseSpace Sequence Hub access is facilitated by an Illumina Connected Analytics (Basic, Professional, or Enterprise) annual subscription. iCredits are used to store data on the cloud platform.
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Illumina Analytics - 1 iCredit
20042038
iCredits are used for data storage and analysis on either BaseSpace Sequence Hub or Illumina Connected Analytics.
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Illumina Analytics Starter Pack - 1,000 iCredits
20042039
iCredits are used for data storage and analysis on either BaseSpace Sequence Hub or Illumina Connected Analytics.
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Illumina Analytics - 5,000 iCredits
20042040
iCredits are used for data storage and analysis on either BaseSpace Sequence Hub or Illumina Connected Analytics.
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Illumina Analytics - 50,000 iCredits
20042041
iCredits are used for data storage and analysis on either BaseSpace Sequence Hub or Illumina Connected Analytics.
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Illumina Analytics - 100,000 iCredits
20042042
iCredits are used for data storage and analysis on either BaseSpace Sequence Hub or Illumina Connected Analytics.
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ICA Basic Annual Subscription
20044874
Illumina Connected Analytics (ICA) Basic Annual Subscription. This product includes 1 year of access to ICA Basic, including sequencing instrument connectivity, data management capabilities, and access to pre-packaged analysis tools.
ICA Professional Annual Subscription
20044876
Illumina Connected Analytics (ICA) Professional Annual Subscription. This product includes 1 year of access to ICA, including sequencing instrument connectivity, data management capabilities, access to pre- packaged tools, and the ability to create customized workflows composed of tools, pipelines, data warehouses, and notebooks.
ICA Enterprise Annual Subscription
20038994
Illumina Connected Analytics (ICA) Enterprise Annual Subscription. This product includes 1 year of access to ICA Enterprise, including sequencing instrument connectivity, data management capabilities, custom and pre-packaged analysis tools, and the Base module for data warehousing and mining. ICA Enterprise also includes optional HIPAA BAA (US-only), single sign-on (SSO), and a service level agreement (SLA).
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Infinium Automated Pipetting System with ILASS (IAPS with ILASS):
Required for post-amplification steps
Infinium Amplification System (IAS):
Optional for pre-PCR steps (whole genome amplification and targeted gene amplification).
These automation instruments offer:
The Infinium Global Clinical Research Array with Enhanced PGx-24 provides the optimal balance of PGx and genome-wide content, throughput, and coverage of diverse populations. The additional content in this array compared with the Infinium Global Screening Array with Enhanced PGx-48 v4.0 are variants associated with disease risk and clinical research. This array has better imputation coverage across even minor allele frequencies compared with screening array solutions from other vendors.
The additional content on this array compared with the Infinium Global Clinical Research Array is the Enhanced PGx content, which includes 100% coverage of priority level A and B CPIC genes and variants from recognized PGx databases such as PharmGKB, PharmVar, CPIC, and ClinVar.
Order an iScan System today. Speak to a representative for information on pricing, availability, and more.
Automation options with robot control software for Infinium assays streamline sample preparation workflows and reduce errors.
This device automatically loads BeadChip microarray carriers onto scanning systems.
Infinium Global Diversity Array (GDA) with Enhanced PGx is the most comprehensive genotyping microarray on the market for pharmacogenomics research.
This microarray is a cost-effective, high-throughput tool for pharmacogenomics (PGx) research and large-scale genotyping studies.
The Global Clinical Research Array offers exceptional coverage of key genome-wide clinical content with a highly scalable workflow.
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