Explore in vitro diagnostic (IVD) instruments designed for the clinical lab environment. With easy-to-follow workflows and integrated software, our IVD instruments deliver accurate, reliable screening and diagnostic testing. Clinical labs can develop and perform their own next-generation sequencing (NGS) tests, run predefined gene panels, or pursue a variety of clinical research applications.
| MiSeqDx Instrument | NextSeq 550Dx Instrument | NovaSeq 6000Dx Instrument | |
|---|---|---|---|
| Key Applications – Diagnostic Mode | Cystic Fibrosis Testing IVD Assay Development Target Enrichment Cancer Companion Diagnostics Future Illumina Assays Future Partner Assays |
IVD Assay Development Future Illumina Assays Future Partner Assays Target Enrichment Noninvasive Prenatal Testing (NIPT) Comprehensive Genomic Profiling (TruSight Oncology Comprehensive EU) |
Targeted Enrichment (Illumina DNA Prep with Enrichment Dx) Future Illumina Assays Future Partner Assays IVD Assay Development |
| Key Applications – Research Mode | Targeted Gene Sequencing (amplicon, gene panel) Metagenomic Analysis Small Whole-Genome Sequencing See More Research Applications |
Exome Sequencing Targeted Gene Sequencing (amplicon, gene panel) Whole-Transcriptome Sequencing Cytogenomic Arrays See More Research Applications |
Whole-Genome Sequencing Targeted DNA Sequencing (high-throughput exome and large custom enrichment panels) Whole-Transcriptome Sequencing Targeted RNA Sequencing (exome, custom enrichment panels) Methylation Sequencing |
| System Software | Fully integrated ecosystem including on-instrument data analysis. Software partitioned for IVD and RUO applications. Diagnostic mode features Local Run Manager software, enabling users to record samples, specify sequencing run parameters, and select analysis modules. | Fully integrated ecosystem including on-instrument data analysis. Software partitioned for IVD and RUO applications. Diagnostic mode features Local Run Manager software, enabling users to record samples, specify sequencing run parameters, and select analysis modules. | Fully integrated ecosystem including paired, on-premise DRAGEN server and license for accelerated secondary analysis. IVD and Research modes enable IVD testing and clinical research applications with no system reboot needed. Illumina Run Manager is integrated on system for simplified run management. Use Illumina BaseSpace Sequence Hub for accurate, rapid secondary analysis. |
| Output Range | ≥ 5 Gb | ≥ 90 Gb | S2: ≥ 1 Tb S4: ≥ 3 Tb |
| Run Time | 24 hours | < 35 hours | S2: ≤ 40 hours S4: ≤ 45 hours |
| Reads per Run | ≥ 15 million | > 300 million | Up to 20 B reads in IVD Mode or Research Mode |
| Maximum Read Length in Diagnostic Mode | 2 × 150 bp | 2 × 150 bp | 2 × 150 bp |
| Samples per Run | Depending on assay | Depending on assay | 8-192 samples/run depending on assay |
| Regulatory Status | For In Vitro Diagnostic Use. Contact us for regional availability. Class II Exempt (US), CE-IVD |
For In Vitro Diagnostic Use. Contact us for regional availability. Class II Exempt (US), CE-IVD |
For In Vitro Diagnostic Use. Contact us for regional availability. Class II Exempt (US), CE-IVD |
| Compatible Products | See All | See All | See All |
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