The future of clinical genomics is here
Welcome to a new era for clinical labs. The NovaSeq 6000Dx is our first IVD-compliant high-throughput sequencing instrument for the clinical lab. Push the boundaries of clinical genomics with scalable throughput and improved economics like never before.
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The NovaSeq 6000Dx features dual modes for IVD and RUO applications, opening new possibilities across a range of sample types, sequencing methods, and clinical research applications.
The NovaSeq 6000Dx system includes a DRAGEN Server paired with the sequencer, enabling streamlined and accurate data analysis. The intuitive software interface makes it easy to maximize your analysis efficiency.
Plan and stagger your sequencing runs and analysis using Illumina Run Manager. Monitor run progress, control instrument, and user management from the instrument or remotely. Illumina Run Manager also helps ensure data security and privacy.
NovaSeq 6000Dx is compatible with Illumina DNA Prep with Enrichment Dx, a rapid library preparation and enrichment solution that works with fixed and custom panels for increased flexibility. Combined with the integrated DRAGEN for Illumina DNA Prep with Enrichment Dx App, the NovaSeq 6000Dx enables a high-throughput clinical testing workflow.
System specifications (IVD mode)
The NovaSeq 6000Dx instrument is part of an integrated, three-step workflow that includes library preparation, high-throughput sequencing in either IVD or RUO modes, and accurate and efficient data secondary analysis with a paired DRAGEN Server.
Prepare libraries with a growing selection of high-performance library prep kits, and manage your workflow with LIMS (Laboratory Information Management System).
Sequence with ready-to-use reagents featuring Illumina sequencing by synthesis chemistry for consistent, reliable data.
Leverage the paired DRAGEN server and menu of DRAGEN applications for accurate and efficient secondary analysis.
From an integrated, unified interface, users can easily switch between RUO and IVD modes to run the NovaSeq 6000Dx instrument, offering the flexibility to perform IVD testing, translational development, and clinical research on a single platform.
Get up and running quickly with a rental or leasing program designed to work with your budget.
Illumina offers a reagent rental program to help labs maximize their budgets while staying competitive. This program is designed to fit the way customers budget for capital purchases and covers all products and countries where we sell direct.
Instrument reliability is crucial for your lab. To maximize uptime, we offer remote monitoring and proactive support to detect potential risks before your run. We offer troubleshooting, maintenance, real-time updates, and more—all in one personal dashboard.
NovaSeq 6000Dx |
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| Regulatory Status | For In Vitro Diagnostic Use | For In Vitro Diagnostic Use | For Research Use Only |
| Key Applications – Diagnostic Mode | Targeted enrichment (Illumina DNA Prep with Enrichment Dx) IVD assay development Future Illumina assays Future partner assays |
Targeted enrichment (Illumina DNA Prep with Enrichment Dx) TruSight Oncology Comprehensive (EU) VeriSeq NIPT Future Illumina assays Future partner assays |
Not available |
| Key Applications – Research Mode | Whole-genome sequencing Targeted DNA sequencing (high-throughput exome and large custom enrichment panels) Whole-transcriptome sequencing Targeted RNA sequencing (exome, custom enrichment panels) Methylation sequencing Explore research applications |
Targeted DNA sequencing (lower throughput exome, smaller custom enrichment panels and amplicon) Whole-transcriptome sequencing Targeted RNA sequencing (exome, custom enrichment and amplicon panels, mRNA-seq and gene expression profiling) Cytogenomic arrays Explore research applications |
Whole-genome sequencing Whole-genome de novo sequencing Targeted DNA sequencing (high-throughput exome and large custom enrichment panels) Whole-transcriptome sequencing Targeted RNA sequencing (exome, custom enrichment panels) Methylation sequencing Explore research applications |
| System Software | Integrated ecosystem including DRAGEN Server and Illumina Run Manager | Local Run Manager | BaseSpace Sequence Hub |
| Analysis | Analysis apps for Illumina DNA Prep with Enrichment (RUO and Dx) available with a graphical user interface on the paired DRAGEN server. Analysis app for Germline (RUO) available with graphical user interface on paired DRAGEN server. BCL Convert app (RUO) available with graphical user interface on paired DRAGEN server. Additional RUO applications enabled through BaseSpace Sequence Hub with a stand-alone DRAGEN server purchased separately. |
Local Run Manager |
Peform clinical applications using the IVD-compliant NovaSeq 6000Dx Library Tube for use with the NovaSeq 6000Dx System.
This IVD-compliant reagent kit provides one NovaSeq S2 flow cell (with 2-lanes) and reagent consumables to support a single flow cell 300 cycles run on the NovaSeq 6000Dx.
This IVD-compliant reagent kit provides one NovaSeq S4 flow cell (with 4-lanes) and reagent consumables to support a single flow cell 300 cycles run on the NovaSeq 6000Dx.
The NovaSeq 6000Dx instrument is intended for targeted sequencing of DNA libraries from human genomic DNA extracted from peripheral whole blood or formalin-fixed, paraffin-embedded (FFPE) tissue when used with in vitro (IVD) diagnostic assays. The NovaSeq 6000Dx instrument is not intended for whole-genome or de novo sequencing. The NovaSeq 6000Dx instrument is intended for use with specific registered, certified, or approved IVD reagents and analytical software.
The NovaSeq 6000Dx instrument is intended for sequencing of DNA libraries when used with in vitro diagnostic (IVD) assays. The NovaSeq 6000Dx instrument is intended for use with specific registered, certified, or approved IVD reagents and analytical software.
With dual operating modes, scalable throughput, and broad flexibility, the NovaSeq 6000Dx will usher in a new era for your clinical laboratory. Contact us today to discuss how the instrument can accelerate your diagnostic and clinical research pursuits.
Your email address is never shared with third parties.
